WEDNESDAY, October 13, 2021 (HealthDay News) – Long-term omega-3 supplementation is associated with an increased risk of atrial fibrillation (AF), according to a study published online October 6 in Circulation.
Baris Gencer, Dr. The meta-analysis comprised seven studies (81,210 patients).
The researchers reported that nearly three quarters of participants (72.6 percent) in studies with 1 g / day and 27.4 percent in studies with> 1 g / day of omega-3 fatty acids were ingested. The average age of the participants was 65 years, with 39 percent women and an average follow-up time of 4.9 years. The meta-analysis showed that the consumption of food supplements containing marine omega-3 fatty acids was associated with an increased risk of atrial fibrillation (2,905; hazard ratio [HR], 1.25), with the risk in the studies with> 1 g / day (HR, 1.49) being higher compared to those with ≤ 1 g / day (HR, 1.12).
“Since the benefits of omega-3 fatty acids also appear to be dose-dependent, the associated AF risk should be weighed against the benefit for atherosclerotic cardiovascular outcomes,” the authors write.
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