The genetic risk for heart disease may be due to a low omega-3 bound biomarker


According to a new study, people who are genetically more likely to have cardiovascular diseases can benefit from boosting a biomarker found in fish oils.

In a genetic study of 1,886 Asian Indians published today (Wednesday, May 12) in PLOS ONE, scientists have the first evidence of the role of adiponectin, an obesity-related biomarker, in the context of a genetic variation called omentin and cardiometabolic health.

The team, led by Professor Vimal Karani of the University of Reading, found that the role of adiponectin was related to markers of cardiovascular disease that were independent of common and central obesity in the Asian Indian population.

Prof. Vimal Karani, Professor of Nutrigenetics and Nutrigenomics at the University of Reading, said:

“This is an important finding on how people who are not obese can develop heart disease from low levels of a biomarker in the body called adiponectin. It can also show why certain lifestyle factors, such as fatty fish consumption and regular exercise, play a role important to stave off the risk of heart disease.

“We studied Asian Indian populations at particular genetic risk for developing heart disease and found that the majority of our participants were already cardiometabolically unhealthy. However, the genetic variation of omentin we studied is widespread in different ethnic groups and.” requires more work See if omentin plays a role in heart disease risk in other groups too. ”

In the Asian Indian population participating in the study, a significant association was found between low adiponectin levels and cardiovascular disease, even after adjusting for factors normally associated with heart disease.

Study participants were screened and rated using a range of cardiovascular measures such as BMI, fasting blood sugar, and cholesterol. More than 80% of the participants were classified as cardiometabolically unhealthy.

Further analysis showed that those with genetic variation in omentin production also had fewer biomarkers of adiponectin in their bodies.

Professor Vimal Karani said:

“What we can clearly see from the observations is that there is a three-step process in which the omentin gene difference contributes to the low biomarker adiponectin, which in turn appears to be linked to poorer outcomes and the risk of heart disease.

“The omentin gene itself produces a protein in the body that has been shown to have anti-inflammatory and cardioprotective effects, and variations in the omentin gene have previously been linked to cardiometabolic disorders. The results suggest that humans are due to cardiometabolic Diseases can develop this specific omentin genetic risk when they have low levels of the biomarker adiponectin. ”


Peer review

Observational study


Disclaimer: AAAS and EurekAlert! are not responsible for the correctness of the press releases published on EurekAlert! by contributing institutions or for the use of information via the EurekAlert system.


Please enter your comment!
Please enter your name here