Study: The Omega-3 Index is a powerful risk predictor of premature death


Sioux Falls, SD –A new paper published in Nature Communications examines the relationship between the omega-3 index and the risk of death for all sorts of reasons. The result: people with higher omega-3 EPA and DHA blood levels (omega-3 index) lived longer than people with lower omega-3 blood levels. As explained in a press release from the nonprofit research and education foundation Fatty Acid Research Institute (FARI), people who died with relatively low omega-3 levels died prematurely. If all else is the same, this publication explains, these people might have lived longer if their level had been higher.

The paper comes from The Fatty Acids and Outcomes Research Consortium (FORCE), which is made up of researchers from around the world who have collected data on blood fatty acid levels in large groups of subjects and followed those people for years to determine which diseases they develop. The current study focused on omega-3 levels and the risk of death during the follow-up period. Thanks to the data gathered by the consortium’s researchers, this is the largest study to date, FARI reported.

The new report is a prospective analysis of pooled data from 17 different
Cohorts from around the world, including 42,466 people, followed for 16 years
average. During this time, 15,720 people died. The analysis found that those who had the highest EPA + DHA levels (i.e., the 90th percentile) had a statistically significant, 13% lower risk of death than those with EPA + DHA levels in the 10th percentile. The researchers examined three main causes of death and found statistically significant risk reductions (comparison of the 90th and 10th percentiles):

  • Cardiovascular diseases: 15% risk reduction
  • Cancer: 11% risk reduction
  • All other causes combined: 13% risk reduction

The researchers found that the results suggest that omega-3 fatty acids may have positive effects on overall health and may slow down the aging process. “Since all of these analyzes have been statistically adjusted for several personal and medical factors (e.g. age, gender, weight, smoking, diabetes, blood pressure, etc. plus omega-6 fatty acid levels in the blood), we believe these are the ones The strongest published data to date supports the view that higher levels of omega-3s in the blood can contribute to better overall health in the long term, ”said Dr. Bill Harris, founder of the Fatty Acid Research Institute (FARI) and lead author on this paper in the publication.

Tom Brenna, PhD, Professor of Pediatrics, Human Nutrition and Chemistry at Dell Medical School, University of Texas at Austin added, “This comprehensive look at observational studies of circulating omega-3s shows that they are long-chain omega-3s -Fatty Acids Trade EPA, DPA and DHA, which are normally derived from seafood, are strongly linked to all-cause mortality, while the levels of vegetable omega-3-alpha-linolenic acid (ALA) are lower. “

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Read the full paper here.


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