A new analysis suggests that the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) did not significantly improve cardiovascular outcomes compared to corn oil.
The paper published in the Journal of the American Medical Association reported the results of the STRENGTH study. STRENGTH was a double-blind, randomized study comparing the omega-3 carboxylic acid formulation of EPA and DHA with corn oil in a patient population of 13,078 statin-treated subjects who had high cardiovascular risk, elevated triglycerides, and low HDL levels. Participants were randomized to receive either 4 g / day omega-3 carboxylic acid (n = 6,539) or corn oil (n = 6,539) plus standard background therapy and statin treatment. The primary endpoint of the study was a combination of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularization, or unstable angina requiring hospitalization.
According to the study results, 1,384 participants experienced a study endpoint event and the study was terminated prematurely due to the low likelihood of clinical benefit of the omega-3 carboxylic acid formulation compared to corn oil. A total of 12,633 completed the study with the determination of the primary endpoint status. The primary endpoint occurred in 12.0% of patients in the omega-3 group versus 12.2% in the corn oil arm (HR = 0.99; 95% CI, 0.90 to 1.09; P = 0.84 ). The authors reported an increase in gastrointestinal side effects in the omega-3 group compared to the corn oil group (24.7% versus 14.7%).
“In statin-treated patients at high cardiovascular risk, the addition of omega-3 carboxylic acid versus corn oil to standard background therapies produced no significant difference in a composite outcome of major cardiovascular adverse events,” the authors concluded. “These results do not support the use of this omega-3 fatty acid formulation to reduce serious adverse cardiovascular events in high risk patients.”
How many coffin nails do we need for omega-3 supplements? Dementia specialists laugh at these vegan doctors who claim n ~ 3 pills protect the brain in some way. I have it in writing. 🤷♂️ https://t.co/1znd7buyPO
– Jeff Nelson (@vegsource) November 15, 2020
Wow, more cold water on EPA / DHA. Also supports the idea that Vascepa studies were mistaken for a non-benign placebo. These links may have some use for TGs, but not what we hoped for in terms of CV risk management https://t.co/C9MZoZsCMe
– Umar Shakur (@u_shakur) November 15, 2020
STRENGTH study: In Pts. If there is a risk of ⬆️CV, there is no difference between 4 g / day omega-3-CA (EPA & DHA) and corn oil for MACE after 38.2 months with the maximum tolerated statin, ⬆️TG & ⬇️HDL. New emerging AFib (ARI 0.9%) and upsetGI upset about Omega-3 CA.https: //t.co/DzmcjrB5jG pic.twitter.com/Nq8oqA8SAT
– Derek Leong (@Derek_Leong_RPh) November 16, 2020