Plasma Omega-3 Fatty Acid Levels Associated with Lower Sudden Cardiac Death Rates in NSTEACS

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April 22, 2021

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Zelniker reports that he was supported by a research grant from the German Research Foundation and has received consultancy fees and fees from AstraZeneca and Boehringer Ingelheim. In the study you will find all relevant financial information from all other authors.

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In patients with non-ST elevated ACS in the ST segment, a higher relative proportion of long-chain omega-3 polyunsaturated fatty acid in plasma was associated with a lower likelihood of sudden cardiac death, researchers reported.

Thomas A. Zelniker

“Although directional consistency across the omega-3 subtypes was observed, the magnitude of the effect appeared to be greatest with the marine-based long-chain omega-3 polyunsaturated fatty acids, including docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid.” Thomas A. Zelniker, MD, MSc, Cardiologist at the Vienna General Hospital of the Medical University of Vienna, and colleagues wrote.

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Zelniker and colleagues analyzed patients with non-ST elevated ACS (NSTEACS) from the MERLIN-TIMI 36 study to determine a relationship between the polyunsaturated omega-3 fatty acid concentration in the plasma chain and the CV results. The cohort included 203 patients who died from a CV cause, 325 patients with MI, 271 patients with ventricular tachycardia, 161 patients with atrial fibrillation, and 1,612 controls with no events.

According to the researchers, patients with higher plasma levels of long-chain omega-3 polyunsaturated fatty acids had an 18% lower chance of CV death after multivariable adjustment (OR = 0.82; 95% CI, 0.68-0.98 ), which was mainly caused by these factors, was 27% lower likelihood of sudden cardiac death (OR = 0.73; 95% CI, 0.55-0.97), while there was no significant association with CV death that was not related to sudden cardiac death.

If the cohort was stratified by quartiles according to the amount of long-chain polyunsaturated omega-3 fatty acids in the plasma, the greater the amount, the lower the probability of sudden cardiac death (P for trend = 0.025), according to the researchers.

In the analysis, patients in the top quarter of long-chain omega-3 polyunsaturated fatty acids in plasma were 51% less likely to have CV death (OR = 0.49; 95% CI, 0.27-0.86) and 63% less chance of sudden cardiac death (OR = 0.37; 95% CI, 0.16-0.56) compared to those in the lower quartile.

According to the researchers, there was no significant relationship between alpha-linolenic acid levels and the subsequent likelihood of CV death (OR = 0.92; 95% CI, 0.74-1.14) and sudden cardiac death (OR = 0.91 ; 95% CI, 0.67-). 1.25).

Zelniker and colleagues also found no significant relationship between omega-3 polyunsaturated fatty acids and the likelihood of CV death unrelated to sudden cardiac death, MI, AF, or early ventricular tachycardia after ACS.

“These data support the theory that certain types of omega-3 supplementation may reduce the risk of undesirable cardiovascular outcomes in higher risk populations,” the researchers wrote.

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